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 Table of Contents  
CASE REPORT
Year : 2017  |  Volume : 3  |  Issue : 4  |  Page : 85-87

Anterior mitral leaflet repair in hypertrophic obstructive cardiomyopathy: A tailored approach under transesophageal echocardiographic guidance


1 Department of Cardiac Anaesthesia, Naryana Hrudalaya Hospital, Bengaluru, Karnataka, India
2 Department of Cardiac Surgery, Naryana Hrudalaya Hospital, Bengaluru, Karnataka, India

Date of Web Publication16-Jul-2018

Correspondence Address:
Sucharita Das
Naryana Hrudalaya Hospital, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kaj.kaj_7_17

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  Abstract 


Hypertrophic obstructive cardiomyopathy (HOCM) is the most common inherited cardiovascular disease, which causes significant involvement of mitral valve in the pathogenesis of left ventricular outflow tract (LVOT) obstruction. A 37-year-old man, a diagnosed case of HOCM, reported to us with complaints of angina and difficulty in breathing. His preoperative echocardiography revealed a predominant LVOT obstruction which caused a resting gradient of 50 mmHg. It was associated with the presence of systolic anterior motion (SAM) and posteriorly directed moderately severe regurgitation jet. Plication of anterior mitral leaflet (AML) was done through transaortic approach while performing septal myectomy. Plicating AML through transaorta was tailored under transesophageal echocardiographic guidance where the height of AML was reduced by 1 cm. As a result, postoperative SAM was significantly reduced. The approach of plicating AML through transaorta became technically simpler with the help of transesophageal echocardiography.

Keywords: Anterior mitral leaflet plication, hypertrophic obstructive cardiomyopathy, septal myectomy


How to cite this article:
Das S, Sridhar S, Rao P V. Anterior mitral leaflet repair in hypertrophic obstructive cardiomyopathy: A tailored approach under transesophageal echocardiographic guidance. Karnataka Anaesth J 2017;3:85-7

How to cite this URL:
Das S, Sridhar S, Rao P V. Anterior mitral leaflet repair in hypertrophic obstructive cardiomyopathy: A tailored approach under transesophageal echocardiographic guidance. Karnataka Anaesth J [serial online] 2017 [cited 2018 Dec 11];3:85-7. Available from: http://www.karnatakaanaesthj.org/text.asp?2017/3/4/85/236808




  Introduction Top


Hypertrophic obstructive cardiomyopathy (HOCM) is the most common inherited cardiovascular disease with substantial genetic and phenotypic heterogeneity, with a prevalence of 0.2%.[1] Most commonly, HOCM is defined as asymmetric hypertrophy of the septum with more involvement of subaortic area or lateral wall, but it can involve middle or apical segments also. Left ventricular outflow tract (LVOT) obstruction is caused by interventricular muscle contraction, which in turn leads to the Venturi effect that causes systolic anterior motion (SAM) of anterior mitral leaflet (AML). Mitral leaflet abnormalities associated with HOCM include long anterior and posterior leaflet,[2] decreased mobility of posterior leaflet, short post coaptation, and septal distance.[3] AML is longer and highly mobile which causes coaptation gap as posterior leaflet [4] is unable to keep up with the mobility of AML. This mechanism, in turn, causes posteriorly directed mitral regurgitation in mid and late systole. Shah et al.,[5] reported that the posterior mitral leaflet coapted with midportion of AML in patients with HOCM with SAM, leaving the distal residual anterior leaflet tip in LV cavity during systole. Patients with an AML length of 33 mm [6] or more benefit from horizontal plication procedure. We report a case where plication of AML reduced SAM significantly.


  Case Report Top


A 37-year-old man, a diagnosed case of HOCM, referred to us with complaints of angina on exertion (Grade 2) and difficulty in breathing (Grade 2) for the past 6 months. His past medical history did not involve any other comorbidities. His routine investigations were within normal limits. His Holter monitoring revealed a maximum heart rate of 96/min (sinus rhythm) and a minimum heart rate of 50/min (sinus rhythm). No sinus pause, supraventricular tachycardia, or ventricular tachycardia was noted during the study [Figure 1]. The patient was taking tablet Norpace (sodium channel blocker) 100 mg OD for the last 1 month. On preoperative transthoracic echocardiography, it was diagnosed that a predominant LVOT obstruction with a maximal septal thickness of 22–24 mm caused a resting gradient of 50 mmHg at the heart rate of 63/min. Mitral valve had elongated leaflets with AML length of 30 mm, with the presence of SAM and posteriorly directed regurgitation jet.
Figure 1: Preoperative echocardiography

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On the day of surgery, after routine induction, the findings of transthoracic echocardiography were confirmed with the use of transesophageal echocardiography (TEE).

TEE findings were LVOT obstruction with proximal segment thickness of maximum 17 mm with a gradient of 97 mmHg at the heart rate of 80/min. AML length was 33.8 mm and PML length was 13 mm. There was a moderate mitral regurgitation jet which was posteriorly directed.

AML plication was done through transaortic approach while doing septal myomectomy. Through the transaortic root, after retracting the aortic leaflets using 6-0 Prolene stay sutures, septal myectomy was performed completely, to relieve LVOT obstruction. After this, AML was inspected and found to be long with increased height. Two horizontal buttress sutures were taken at the base of AML just below the subaortic curtain. These two horizontal pledgeted sutures (5 mm on each side) were taken at the base of AML just opposite to A2. Hence, the length of AML was reduced almost by 1 cm. Aortic closure was performed using 4-0 Prolene continuous sutures. The patient came of bypass with minimal support of noradrenaline 0.02 μg/kg/min.

Postoperative TEE showed no SAM, LVOT gradient of 12 mmHg, and no mitral regurgitation with competent aortic valve [Figure 2]. Proximal segment thickness was 13 mm, length of AML was approximately 21 mm, and length of PML was 13 mm with coaptation height 0.9 mm.
Figure 2: Postoperative echocardiography

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The patient was extubated within 6 h and was shifted from the Intensive Care Unit within 36 h. He was discharged from the hospital on the 5th postoperative day.


  Discussion Top


Mitral valve repair is feasible in 50%–60% of these HOCM patients using combined reparative technique.[6] Plication of the anterior leaflet of the mitral valve with myectomy was first proposed by Intosh et al.[7] It was performed in those patients who were at risk for unstable hemodynamics as a result of mitral valve pathology (increased mobility, size, or length of AML with respect to LVOT), which can lead to systolic motion of AML. Repair of mitral valve in HOCM patients to relieve SAM is controversial where the selection of patients may be important. Plication of elongated AML not only reduces length of the leaflet but also gives stiffness to the leaflet,[8] which may prevent SAM. TEE guides surgeon to assess the length in step by step, so it has become an integral part of the surgery. There are different commonly described techniques available to reduce the length of AML such as AML resection, sliding leaflet, or Alfieri edge-to-edge repair, but our case describes a method where elongation was reduced by plication of AML through transaortic approach. Balaram et al.[8] described the technique of “Resection–Plication–Release” to deal with the height of AML.

In our case, predictors of SAM in TEE were AML length >3.2 cm,[6] C-sept <2.5 cm, small LVOT (16 mm), and AML/LVOT >2.[2] Preoperative assessment helped us to tailor precisely the length of AML.

The length of AML was reduced almost 1 cm by taking two horizontal buttress sutures at the base of AML just below the subaortic curtain which eliminated systolic anterior motion. The use of TEE helped surgeons to find the procedure more simple.


  Conclusion Top


AML plication in HOCM patients through transaorta is a technically safe procedure when guided by TEE. It helps us not only to compare pre- and postoperative data but to find out complications [4] at all, if associated. Traditional approach of placating AML through left atrium adds another incision which triggers postoperative arrhythmia. Hence, the use of transaortic route helps major way to reduce arrhythmia. TEE has become an integral part in cardiac surgery, as in almost all cases, it has a diagnostic value.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE, et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary artery risk development in (Young) adults. Circulation 1995;92:785-9.  Back to cited text no. 1
    
2.
Maron MS, Olivotto I, Harrigan C, Appelbaum E, Gibson CM, Lesser JR, et al. Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic expression of hypertrophic cardiomyopathy. Circulation 2011;124:40-7.  Back to cited text no. 2
    
3.
Shah PM, Taylor RD, Wong M. Abnormal mitral valve coaptation in hypertrophic obstructive cardiomyopathy: Proposed role in systolic anterior motion of mitral valve. Am J Cardiol 1981;48:258-62.  Back to cited text no. 3
    
4.
Grigg LE, Wigle ED, Williams WG, Daniel LB, Rakowski H. Transesophageal Doppler echocardiography in obstructive hypertrophic cardiomyopathy: Clarification of pathophysiology and importance in intraoperative decision making. J Am Coll Cardiol 1992;20:42-52.  Back to cited text no. 4
    
5.
Cavalcante JL, Barboza JS, Lever HM. Diversity of mitral valve abnormalities in obstructive hypertrophic cardiomyopathy. Prog Cardiovasc Dis 2012;54:517-22.  Back to cited text no. 5
    
6.
Kaple RK, Murphy RT, DiPaola LM, Houghtaling PL, Lever HM, Lytle BW, et al. Mitral valve abnormalities in hypertrophic cardiomyopathy: Echocardiographic features and surgical outcomes. Ann Thorac Surg 2008;85:1527-35, 1535.e1-2.  Back to cited text no. 6
    
7.
McIntosh CL, Maron BJ, Cannon RO 3rd, Klues HG. Initial results of combined anterior mitral leaflet plication and ventricular septal myotomy-myectomy for relief of left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy. Circulation 1992;86:II60-7.  Back to cited text no. 7
    
8.
Balaram SK, Tyrie L, Sherrid MV, Afthinos J, Hillel Z, Winson G, et al. Resection-plication-release for hypertrophic cardiomyopathy: Clinical and echocardiographic follow-up. Ann Thorac Surg 2008;86:1539-44.  Back to cited text no. 8
    


    Figures

  [Figure 1], [Figure 2]



 

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